Senior Scientist Assay Development
On-site, Full time
About the job
Altheome is a biomarker and proteomics specialist advancing precision medicine through cutting-edge analytical platforms. With expertise in ultrasensitive immunoassays and next-generation proteomics, Altheome delivers unmatched sensitivity and scale in biomarker measurement. We partner with pharmaceutical organisations, biotechnology companies, and academia to accelerate discovery, validate biomarkers, and translate insights into clinical impact. By bridging discovery and application, Altheome is shaping the future of biomarker-driven diagnostics and therapies.
The Senior Scientist – Assay Development will lead the design, development, optimization, and validation of in vitro diagnostic assays for research and clinical applications. This role requires hands-on laboratory work, regulatory compliance, and cross-functional collaboration with the other teams to ensure successful product development and its commercialization.
You should have a strong understanding of the conceptual and practical application of the scientific framework for validation parameters, including but not limited to: standard curves and calibration, determination of Hook effect, dilution linearity, parallelism, and spike recovery. You should be confident with establishing assay performance, assay optimisation, intra- and inter-assay precision determination. Custom assay development on proteomic platforms including NULISA, SIMOA, and MSD, are especially valued.
You should preferably have a good understanding of the ICH guideline M10 on bioanalytical method validation, and strong experience with custom assay development on LBA formats including ELISA.
Key Responsibilities
Develop custom assays for internal R&D and external clients, on platforms including NULISA, SIMOA and MSD.
Design and execute experiments to develop assays and establish assay performance specifications (sensitivity, specificity, reproducibility) and validation (Hook effect, dilution linearity, parallelism, spike recovery).
Optimize and troubleshoot assays to meet performance expectations.
Participate in technical discussions and project meetings.
Design and execution of verification and validation (V&V) studies, including all testing and documentation.
Perform data analysis and generate study reports.
Identify and troubleshoot assay or process issues, recommend solutions, and contribute ideas for assay and process improvements.
Stay current on relevant technological and scientific advancements through literature review and evaluation of emerging technologies.
Requirements
B.Sc., M.Sc, or Ph.D. in Biochemistry, Molecular Biology, Immunology, or related fields.
5+ years in custom assay development and validation.
Hands-on experience with immunoassay formats (ELISA, chemiluminescence).
Additional format including enzymatic assays, and molecular techniques (qPCR, sequencing) preferred but not essential.
Knowledge and experience working within regulatory frameworks (e.g., FDA 21 CFR Part 820, ISO 13485, GCP, HTA) preferred but not essential.
Proficiency in data analysis tools (Excel, GraphPad Prism, or statistical software).
Experience with Design of Experiment (DoE) preferential but not essential.
Excellent documentation and communication skills.
How to Apply
Please submit your CV to careers@altheome.com or directly via our LinkedIn job posting.
Please Note:
The title and compensation are commensurate with the level of experience & expertise.
If this role sounds like a good fit for you, we’d love to hear from you.
Senior Scientist Assay Development
On-site, Full time
About the job
Altheome is a biomarker and proteomics specialist advancing precision medicine through cutting-edge analytical platforms. With expertise in ultrasensitive immunoassays and next-generation proteomics, Altheome delivers unmatched sensitivity and scale in biomarker measurement. We partner with pharmaceutical organisations, biotechnology companies, and academia to accelerate discovery, validate biomarkers, and translate insights into clinical impact. By bridging discovery and application, Altheome is shaping the future of biomarker-driven diagnostics and therapies.
The Senior Scientist – Assay Development will lead the design, development, optimization, and validation of in vitro diagnostic assays for research and clinical applications. This role requires hands-on laboratory work, regulatory compliance, and cross-functional collaboration with the other teams to ensure successful product development and its commercialization.
You should have a strong understanding of the conceptual and practical application of the scientific framework for validation parameters, including but not limited to: standard curves and calibration, determination of Hook effect, dilution linearity, parallelism, and spike recovery. You should be confident with establishing assay performance, assay optimisation, intra- and inter-assay precision determination. Custom assay development on proteomic platforms including NULISA, SIMOA, and MSD, are especially valued.
You should preferably have a good understanding of the ICH guideline M10 on bioanalytical method validation, and strong experience with custom assay development on LBA formats including ELISA.
Key Responsibilities
Develop custom assays for internal R&D and external clients, on platforms including NULISA, SIMOA and MSD.
Design and execute experiments to develop assays and establish assay performance specifications (sensitivity, specificity, reproducibility) and validation (Hook effect, dilution linearity, parallelism, spike recovery).
Optimize and troubleshoot assays to meet performance expectations.
Participate in technical discussions and project meetings.
Design and execution of verification and validation (V&V) studies, including all testing and documentation.
Perform data analysis and generate study reports.
Identify and troubleshoot assay or process issues, recommend solutions, and contribute ideas for assay and process improvements.
Stay current on relevant technological and scientific advancements through literature review and evaluation of emerging technologies.
Requirements
B.Sc., M.Sc, or Ph.D. in Biochemistry, Molecular Biology, Immunology, or related fields.
5+ years in custom assay development and validation.
Hands-on experience with immunoassay formats (ELISA, chemiluminescence).
Additional format including enzymatic assays, and molecular techniques (qPCR, sequencing) preferred but not essential.
Knowledge and experience working within regulatory frameworks (e.g., FDA 21 CFR Part 820, ISO 13485, GCP, HTA) preferred but not essential.
Proficiency in data analysis tools (Excel, GraphPad Prism, or statistical software).
Experience with Design of Experiment (DoE) preferential but not essential.
Excellent documentation and communication skills.
How to Apply
Please submit your CV to careers@altheome.com or directly via our LinkedIn job posting.
Please Note:
The title and compensation are commensurate with the level of experience & expertise.
If this role sounds like a good fit for you, we’d love to hear from you.
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© 2025 Altheome Limited. All Rights Reserved.